Quinoline anti-malarial drugs inhibit spontaneous formation of β-haematin (malaria pigment)

The use of anti-malarial drugs to prevent malaria in the population of malaria-endemic areas.

Anti-malarial drugs have been used in various ways to prevent malaria in the resident populations of endemic areas for nearly 100 years. The primary aim of most early studies was to interrupt transmission. This was rarely achieved, but administration of anti-malarial drugs either through medication of salt or by mass administration frequently led to a marked reduction in the prevalence of malar...

Bile pigment formation in vitro from haematin and haem derivatives.

in the form of methaemoglobin, but was apparently accounted for as carboxyhaemoglobin after the addition of carbon monoxide and dithionite. 4. The green pigment is distinct from choleglobin, and its formation is not prevented by carbon monoxide, showing that oxyhaemoglobin is not an intermediate in the reaction. We wish to thank Mr B. A. Collett for technical assistance during a part of the work.

Evaluation of anti-malarial activity of Artemisia turcomanica and A. kopetdaghensis by cell-free β-hematin formation assay

Background and objectives:The plants of genus Artemisia (Asteraceae) have been conventionally used for prevention and medication of a number of ailments. In the present research, ten extracts with different polarities from aerial parts of two Artemisia species, A. kopetdaghensis and A. turcomanica were evaluated for their potential anti-malar...

The history of anti-malarial drugs.

Fluorine and sulfur quinoline derivatives as anti-malarial agents.